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filingDate 2017-06-07^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a408f204eb39f3ef302e6e91d5edc21
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publicationDate 2019-08-20^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10386361-B2
titleOfInvention Long term hematopoietic stem cell specific reporter mouse and uses thereof
abstract Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC in bone morrow; production of LT-HSC from pluripotent stem cells such as iPS cells; for analysis of early stage LT-HSC; in screening methods for expansion and manipulation of LT-HSC, and the like.
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