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filingDate 2018-10-08^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c24cb8cb53c51138dddc3b60dd216560
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publicationDate 2020-06-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10695327-B2
titleOfInvention Macrocyclic lactone compounds and methods for their use
abstract A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: n nwherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , M 1 , M 2 , M 3 , M 4 , M 5 , M 6 and M 7 are each independently a member selected from the group consisting of H, C 1-6 alkyl, OH and C 1-6 hydroxyalkyl; R 4 , R 7 and R 9 are each independently selected from the group consisting of C 1-6 alkoxy and OH; R 10 is a member selected from the group consisting of H, —OH, —OP(O)Me 2 ,n n n—O—(CH 2 ) n —OH and —O—(CH 2 ) m —O—(CH 2 ) o —CH 3 , wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L 1 and L 4 are independently selected from the group consisting of:n n nwherein each M 8 is independently a member selected from the group consisting of C 1-6 alkyl, OH and C 1-6 hydroxyalkyl; each of L 2 and L 3 are independently selected from the group consisting of:n n nand salts, isomers, or N-oxides thereof.
priorityDate 2006-09-13^^<http://www.w3.org/2001/XMLSchema#date>
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