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filingDate 2020-12-14^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-06-29^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4b6531314a491c28002536b77e1a3a0
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publicationDate 2021-06-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11045651-B2
titleOfInvention Method and apparatus for multimodal electrical modulation of pain
abstract Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.
priorityDate 2015-03-20^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID1016
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID19225
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO77620
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID161166
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID395764
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1727
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID2405
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID16183
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226411862
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID6134
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7NDN8
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281251
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100135607
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9XS38
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID280822
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0GC71
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9XS77
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ95M53
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6T752
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP01584
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ08081
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID968
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2LT65
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2MH07
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID396623
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID818183
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2LT64
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4UYK8
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID10116
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID395247
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100052414
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ63264
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0A7D9NKA2
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100034237
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ62432
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID20318
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID813
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9XT84
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9XT83
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCE9PTD9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7JFM5
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID60961
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID455407
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7JFM4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCE1BNK3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7JFM3
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5743
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7JFM2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ66I23
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP60569
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID12514
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281958
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCF6U272
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID15488
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID55310
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403974
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID443460
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3553
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403989

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