| abstract |
The present invention relates to ethynyl derivatives of formula I n nwith variables as defined herein, or to a pharmaceutically acceptable acid addition salt thereof.n n Compounds of formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of, e.g., anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD). |