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filingDate 2020-08-12^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-09-21^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92f0b189a91d28db508a638d6471fe3f
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publicationDate 2021-09-21^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-11123428-B2
titleOfInvention Inactivating bacteria with electric pulses and antibiotics
abstract Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.
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