http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180449-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca51161b85cee1aacdb801d5253c1028 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 |
| filingDate | 2021-06-08^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bd6b2379133c61c080aab963456f8be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff5ba7763037cd45849f91a3e762a69f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689787819db240290ebb5e49f4fd86a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56e12bd66d8463b436a638461945ede1 |
| publicationDate | 2021-11-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-11180449-B2 |
| titleOfInvention | Crystal form of key intermediate of bruton tyrosine kinase (BTK) inhibitor and preparation method thereof |
| abstract | The present disclosure relates to a crystal form of a key intermediate of a bruton tyrosine kinase (BTK) inhibitor and a method for preparing the crystal form, and belongs to the technical field of medicine. The crystal form is a crystal form II of (R)-1-(1-(tert-butyloxyl)pyrrolidine-3-yl)-3-cyano-4-(4-(2,6-difluorophenoxyl)phenyl)-1H-pyrrole-2-ethyl formate. The obtained crystal form II of (R)-1-(1-(tert-butyloxyl)pyrrolidine-3-yl)-3-cyano-4-(4-(2,6-difluorophenoxyl)phenyl)-1H-pyrrole-2-ethyl formate has good chemical stability and crystal form stability and is convenient for storage and transportation. Meanwhile, the intermediate can be highly purified and a sample with a purity of 99.7% is obtained. The crystal form is important for quality control of a BTK inhibitor (R)-4-amino-1-(1-(butyl-2-alkynyl)pyrrolidine-3-yl)-3-(4-(2,6-difluorophenoxyl)phen yl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one, has a simple preparation process and is suitable for industrial production. |
| priorityDate | 2019-07-09^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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