http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11242562-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4f16e71d2cc81c549e81470d725e224 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-514 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2535-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2535-119 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-179 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-179 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6876 |
| filingDate | 2018-08-30^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-08^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c9c4fd7831c65288ad3f3ef69627fd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44776c90d178d1ba81c94bfa18fd083a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61db330e96a5de56b7ea495a536bfa7b |
| publicationDate | 2022-02-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-11242562-B2 |
| titleOfInvention | Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing |
| abstract | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11761035-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739367-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11788139-B2 |
| priorityDate | 2012-03-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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