abstract |
The present invention relates to a novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D 3 and D 4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, n n n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and n are the same as defined in the specification. |