| abstract |
Compound of formula (I): n n n wherein: n X represents a bond or alkylene, CO, S(O) n , —S(O) n —A 1 —, —CO—A 1 —, —A—S(O) n —A′ 1 — or —A 1 —CO—A′ 1 —, n Y represents aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted, n R 1 , R 2 , R 3 and R 4 each independently of the others represent hydrogen or aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted, n or R 1 , R 2 , R 3 and R 4 , taken in pairs, together form a bond, or form a fused benzene ring or a fused aromatic or partially unsaturated heterocycle, n T represents —CH(R 5 )—, —N(R 5 )— or —N(R 5 )CO—, n V represents hydrogen or unsubstituted or substituted aryl or heteroaryl, n A 2 represents [C(R 6 )(R′ 6 )] p , n R 7 and R 8 are as defined in the description, n their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as farnesyl transferase inhibitors. |