| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10352
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0621
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0091
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2002-04-18^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67e3d7216b463e747e7f5979f02fe907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_238527ea70dd4c6579966a676538a687
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0fdd7aed6d6e15a989baef82543d645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e5f42338a26c7e476086c6de003e864
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8df3e10919e59e51f747ab519ea80a62 |
| publicationDate |
2002-11-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002173039-A1 |
| titleOfInvention |
Packaging systems for human recombinant adenovirus to be used in gene therapy |
| abstract |
Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinant adenoviruses. A system for use with the invention produces replication defective adenovirus. The system includes a primary cell containing a nucleic acid based on or derived from adenovirus and an isolated recombinant nucleic acid molecule for transfer into the primary cell. The isolated recombinant nucleic acid molecule is based on or derived from an adenovirus, has at least one functional encapsidation signal and at least one functional Inverted Terminal Repeat, and lacks overlapping sequences with the nucleic acid of the cell. Otherwise, the overlapping sequences would enable homologous recombination leading to replication competent adenovirus in the primary cell into which the isolated recombinant nucleic acid molecule is to be transferred. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7052881-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006246569-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003104626-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7105346-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236293-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005260596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009023196-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004228843-A1 |
| priorityDate |
1995-06-15^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |