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filingDate 2002-04-05^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b75c84de1fc8f55ccb27baa11a978e6d
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publicationDate 2002-12-12^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2002187543-A1
titleOfInvention Enhanced dispersion of adenoviral vectors by fusogenic membrane glycoproteins
abstract The present invention provides a method of increasing adenoviral vector dispersion within tumor mass by inducing syncytia formation with fusogenic membrane glycoproteins. These data demonstrate the utility of fusogenic membrane glycoproteins as dispersion agents and suggest that fusogenic membrane glycoproteins can improve the efficacy of conditionally replicative adenovirus gene therapy.
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