| abstract |
This invention describes novel pyrazole compounds of formula II: n n n wherein Z 1 is nitrogen or CR 8 ; Q is —S—, —O—, —N(R 4 )—, or —CH(R 6 )—; R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R y , R 2 , and R 2 ′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease. |