| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82b253c44e447900a2998dbb3ea8fa64 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1658 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B8-00 |
| filingDate |
2002-06-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c4dd712285a921ca399b8a72b1e3a8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_668751c2073cc1f548668632aaf44f0f |
| publicationDate |
2003-07-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003133876-A1 |
| titleOfInvention |
Preparation of further diagnostic agents |
| abstract |
Microspheres are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microsphere have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 μm, targeted to selected areas of the body or of prolonged life in the circulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8020313-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010178245-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010206709-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008019904-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8322046-B2 |
| priorityDate |
1992-10-10^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |