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titleOfInvention Bispecific antibody point mutations for enhancing rate of clearance
abstract A mutant bispecific antibody that includes (a) a human hinge constant region from IgG having one or more amino acid mutations in the C H 2 domain, (b) two scFvs; and (c) two Fvs has been constructed. This type of antibody displays enhanced clearance, which has been found to be particularly useful in the context of pre-targeting methods.
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