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publicationDate 2004-09-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2004191261-A1
titleOfInvention Fibrin/fibrinogen-binding conjugate
abstract A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF 165 C-terminal domain fused to a wound-healing substance such as leptin.
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