| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1209eded072f475d14eb89ae5fc7fa23 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-13039
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2004-03-24^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56d75763dd0f450166e880331228ef93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d445e69e70dd884fce187d81d8b5416b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cff6197517225f11cb124afecfebd2f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e7a19079efbec0f1710dfacd0d7de4e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bd360defa5c2b2d48cda717ae895aa7 |
| publicationDate |
2005-04-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005074448-A1 |
| titleOfInvention |
Method of treatment of endothelial dysfunction and engineered proteins for same |
| abstract |
Endothelial cells produce many factors that are involved in maintaining blood vessels. One of the best understood and most studied factor is nitric oxide (NO), which is produced by an endothelial enzyme called nitric oxide synthase (eNOS). The present invention provides a molecule designed to be delivered to the endothelium where it can reconstitute eNOS activity and restore NO production. Thus, the present invention provides methods of detecting, treating and preventing diseases or disorders associated with the vasculature and denoted by reduced levels of eNOS in the endothelium, as well as a concomitant reduction in the amount of NO that can be produced. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008234659-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009214645-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2703567-C1 |
| priorityDate |
2003-03-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |