http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005150275-A1

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filingDate 2004-01-13^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b48d0aa44cfa6492913bd6830185a20d
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publicationDate 2005-07-14^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2005150275-A1
titleOfInvention Process monitoring and particle characterization with ultrasonic backscattering
abstract A fermention process is monitored by detecting ultrasound backscattered from the cells as a function of time. A transducer 46 is placed in a fermentor 30 and transmits ultrasound towards a reflecting surface 50 . The transducer receives that portion of the ultrasound which reflects from the reflecting surface 50 , as well as that portion of the ultrasound which backscatters from cells 34 between the transducer 46 and the reflecting surface 50 . Signals from the transducer are conditioned and subsequently processed to provide output to a controller regarding the status of the fermentation process in real time. The backscattering measurements can be used to determine a growth phase transition, such as the transition between the logarithmic growth phase of the cells and their stationary phase.
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