http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005234257-A1

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_858b36acfb2e01710cb1293b17ab1c08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f00083fe0c7ed56ef2dd68fb9074c195
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4025
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40
filingDate 2005-05-25^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaf2fac04be7781c8737505b81fefe7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_380181196dec0eab41fb5113b4e75674
publicationDate 2005-10-20^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2005234257-A1
titleOfInvention Facile synthesis of symmetric esters of alkylenebisphosphonic acids
abstract A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1 H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.
priorityDate 2001-04-11^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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