http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006183925-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_257e52a8fcb6658dc74983b64fd511b7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2004-03-09^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5eaaed784ebf74fde1ae7d6f50c4ea2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c98ae2501d975a8483341552bbf96f98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8db5b1bc2800358e36f9eda49b37f192 |
| publicationDate | 2006-08-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2006183925-A1 |
| titleOfInvention | Process for the preparation of a cyano-isobenzofuran |
| abstract | A process for the preparation of citalopram and the pharmaceutically acceptable salts therof is disclosed by reacting 5-cyanophthalide with a 4-fluorophenyl magnesium halide, reducing the 3-hydroxymethyl-4-(4-fluorobenzoyl)benzonitrile with an agent reducing ketones to alcohols, submitting the thus-obtained 3-hydroxymethyl-4-[(4-fluorophenyl)hydroxymethyl) benzonitrile to a cyclization reaction to give 1-(4-fluorophenyl)-1,3-dihydro-5isobenzofurancarbonitrile without 1,1-bis(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile and treating 1,1-bis(4 fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile with a 3-(dimetylamino)propyl halide in the presence of a base. |
| priorityDate | 2003-03-13^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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