abstract |
A method for the preparation of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (CF 3 CHFOCHF 2 , Desflurane) is provided, which comprises reacting CF 3 CHClOCHF 2 (isoflurane) and hydrogen fluoride in the presence of antimony pentafluoride such that desflurane is formed. |