| abstract |
Pharmaceutical compositions and methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise and other toxic insults are provided. These methods comprise administering an effective amount of a protectant combination or composition comprising two or more protectants selected from the group of methionine protectant agents, N-acetylcysteine, carnitine, magnesium ions, lipoic acid, ebselen, glutathione, and glutathione ester. These protectant combinations can be administered prior to, simultaneously with, or subsequently to exposure to noise other toxic insults. |