| abstract |
The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells, or both, from CD14 + monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD14 + monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14 + monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells. n The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models. |