| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9418dff6cccdcef9f76c3c652e0c52cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a8f35bb0cd48a0d24390cd8c7187174
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24085e384e3579d817329df170b7927e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b87a3c5919d22a63c59453835a79d99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b7e64bc0d988b01616ee5edeb4342af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd98df344dedd222630a251ba88455ae |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-624
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-06166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30677
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2210-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-914
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2250-0035 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-30756
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate |
2009-05-08^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d542a7c894287b3c4fcdaa69396cb8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a1592759a77be83758d81b48a464f36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f32b5182478fddff8ad10b4c7dd5dd4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbfaed21cb4fc129152b7901d8e72008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e68df6281c83b252893e46a85ba6e053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd9fa358af8b017fef00cc4169faf8ae |
| publicationDate |
2009-12-03^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009297605-A1 |
| titleOfInvention |
Composition And Device For In Vivo Cartilage Repair |
| abstract |
The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained. |
| priorityDate |
1997-08-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |