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http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_720780e663f20854254e953d62fa9d18
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publicationDate 2011-01-27^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2011020385-A1
titleOfInvention COMBINATIONS OF PNEUMOCOCCAL RrgB CLADES
abstract Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
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type http://data.epo.org/linked-data/def/patent/Publication

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