| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_006e91eddabe95ad7aa889123d31cb9a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2011-03-09^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22dac908a3adce66883605cc5c1b3fa9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccec9352d29b5d77d16a26320335df6a |
| publicationDate |
2011-06-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011158991-A1 |
| titleOfInvention |
Cytotoxic agents comprising new maytansinoids |
| abstract |
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4015532-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016192527-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10960082-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017088734-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014114207-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018091724-A1 |
| priorityDate |
2003-05-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |