| abstract |
The present invention provides cyclopropyl-fused-1,3-thiazepines of formula I n n n n n n n n n n having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes. |