| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6582742e4bec2d62f0a2b1c1dfdc7c36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a4e19d34b6927320098948fa50d99e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2011-02-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_506ec0836e4b553cb7f78e19e760b3dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97ad348a95ecc1bca9b2373e6927da61 |
| publicationDate |
2013-02-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013052259-A1 |
| titleOfInvention |
Liposomes comprising amphipathic drugs and method for their preparation |
| abstract |
The present invention provides a liposome having co-encapsulated in its intraliposomal aqueous core at least two amphipathic drugs, the liposomes being characterized by one of the following: the amphipathic drugs are co-encapsulated at a pre-determined ratio; the liposome comprises one or a combination of liposome forming lipids have a solid ordered to liquid disordered phase transition temperature above 37° C.; each of the amphipathic drugs exhibit a liposomal profile that corresponds to the profile of each drug when encapsulated as a single drug in the same liposome; and the liposome is absent of one or both of a transition metal and a ionophore. The invention also provides a method for preparing such liposomes. This method, taken together with the features of the liposomal composition, provides high loading and long term stability of the resulting co-encapsulated liposomal formulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10413511-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11413244-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10617672-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017066667-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019022004-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3324969-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11559486-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013259922-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018153805-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2020274094-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11446247-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014144365-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11260033-B2 |
| priorityDate |
2010-02-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |