| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e314cfc1168edc501a3e7c18d895d6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7eca6055d083a2068a34770790220eae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca98bbcdad3225ced7c79ac074364aad |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-686 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2011-03-11^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6587703d0f65f1dbdc24579922ffbb34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_612be2e1ae93f810ca6c87dcaee0de01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eed75188b7fb36efa51f1171fee5953 |
| publicationDate |
2013-03-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013071842-A1 |
| titleOfInvention |
Hypermethylation Biomarkers for Detection of Head and Neck Squamous Cell Cancer |
| abstract |
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadChip, publicly available methylation and expression array data, and Quantitative Methylation Specific PCR to uncover differential methylation in OSCC clinical samples with heterogeneous risk profiles. A two stage-design consisting of Discovery and Prevalence screens was used to identify differential promoter methylation and deregulated pathways in patients diagnosed with OSCC and head and neck squamous cell carcinoma. This Phase I Biomarker Development Trial identified a panel of differentially methylated genes in normal and OSCC clinical samples from patients with heterogeneous risk profiles. This panel may be useful for early detection and cancer prevention studies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020219514-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022155679-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110229909-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10457992-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015066170-A1 |
| priorityDate |
2010-03-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |