| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7de02e4b28736bfb52de8bb358be203e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1fb87cd463b69ff93a6f7bd743936563
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20d9485eb5f54d7a349e979b7c98837f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-198 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2011-08-15^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e8a08660d57c37acef3e8d484227e13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f823804d40302b290571eedebb0e7e65 |
| publicationDate |
2013-07-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013184330-A1 |
| titleOfInvention |
Compositions and methods for inducing cancer cell death |
| abstract |
Described herein are pharmaceutical compositions including a sugar or mannose analog (e.g., 2-DG) and an inhibitor of at least one of PERK and GCN2 (e.g., an inhibitor of PERK and an inhibitor of GCN2) for treating cancer, and methods of treating cancer in a subject involving administration of these pharmaceutical compositions. Pharmaceutical compositions [or inducing death of cancer cells include a therapeutically effective amount of a pharmaceutical composition including: a pharmaceutically acceptable carrier, a sugar analog in an amount effective for inhibiting the growth of cancer cells, and an inhibitor of at least one of: PERK and GCN2 in an amount effective for blocking phosphorylation of eif2-1″t in the cancer cells, wherein the combined amounts of the sugar analog and the inhibitor of at least one of: PERK and GCN2 are sufficient for inducing death of the cancer cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016166574-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9861635-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730750-B2 |
| priorityDate |
2010-08-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |