| abstract |
Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: n n n n n n n n n n n n wherein Ar represents n n n n n n n n n n n n n n n n R 5 , R 7 , R 8 , R 2 ′, R 4 ′, R 5 ′, R 6 ′, R 7 ′, R 8 ′ independently represent H, OH, F, Cl, Br, methoxyl group, NH 2 group or NMe 2 group; X represents NH, O or S; and R 6 is selected from the group consisting of: pyrrolidinyl group, piperidinyl group, morpholino group, methoxyl group, and dimethylamine group. The present invention also provides a composition comprising the compound of formula I. The compound and the composition in accordance with the present invention are effective on treating or alleviating a disease or disorder, such as malignant glioma. |