http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014234961-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23d951ac62027f82516dfb9a90584e34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84f4e307c3d530a910727cc7c7ec1daa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6807 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-484 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2013-11-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05f46aafcc90c5853754d7a0cf0a0a22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95329b26f336eebd8acc87bc751f109f |
| publicationDate | 2014-08-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2014234961-A1 |
| titleOfInvention | SYNTHETIC SINGLE CHAIN VARIABLE DOMAIN (SCFV) IMMUNOGLOBULIN FRAGMENT VEHICLE CONTAINING FUSION PROTEINS FOR TARGETED INTRODUCTION OF siRNA |
| abstract | A fusion protein and process are provided by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues. A cell surface receptor specific synthetic single chain variable domain (scFv) immunoglobulin fragment vehicle specific to a cell surface receptor of the cell and having a cell surface receptor specific binding site is provided. An RNA binding protein fused to said scFv is adsorbed with a double-stranded RNA or to a small hairpin RNA sequence complementary to a nucleotide sequence of a target gene in the cell and includes a small interfering RNA operative to suppress production of a target cellular protein. The scFv induces internalization into said cell of the fusion protein subsequent to the binding of said scFV to the cell surface receptor of the target cell. |
| priorityDate | 2012-11-05^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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