http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015330990-A1

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filingDate 2014-06-13^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-11-19^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2015330990-A1
titleOfInvention Method of screening candidate biochemical entities targeting a target biochemical entity
abstract Described herein are methods useful for screening candidate biochemical entities targeting a target biochemical entity and methods useful for identifying a binding moiety for a target biochemical entity. The invention provides methods of screening drug candidates targeting a target biomolecule, comprising selecting a drug candidate based on a signal difference between a first signal and a second signal. The signal difference indicates a difference in an in vivo or in vitro pharmacological property. The first signal is produced upon binding between the target biomolecule and a first candidate by contacting the target biomolecule with the first candidate, and the second signal is produced upon binding between the target biomolecule and a second candidate by contacting the target biomolecule with the second candidate.
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