| abstract |
A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); n n n n n n (Sequence ID No. 3) n n n n Xaa 1 -Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg- n n n n Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser- n n n n Ser-Gly-Ala-Pro-Pro-Pro-Ser (3) n n n n n n n n n n n n n n n n n where Xaa 1 represents an aspartic acid in which a —Y—X′ group binds to an α-amino group, X′ includes a chelating site and a radioactive metal nuclide chelated by the chelating site, the chelating site being diethylenetriaminepentaacetic dianhydride (DTPA) or 1,4,7-triazacyclononnane-N,N′,N″-triacetic acid (NOTA), and Y represents a linker including a group selected from the group consisting of —CH 2 —(C 6 H 4 )—, —NH—C(═S)—, —NH—(CH 2 ) 5 —C(═O)—, and a combination thereof. |