| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_726cc224c76ca555aff94bcef0528b28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-197
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C239-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-662
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3264 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-197
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-662 |
| filingDate |
2016-06-14^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80122f472088b555d798fb414a0eacb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba0c114ed685f478e8f3c83f9167971b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_069b319c1d938f2376a73007edcf2ed6 |
| publicationDate |
2016-10-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016296484-A1 |
| titleOfInvention |
Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| abstract |
β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109174181-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016346240-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10034847-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10017459-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9682921-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9783487-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9937139-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9861599-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10245246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10246406-B2 |
| priorityDate |
2014-02-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |