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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d9945ae9ea7259c1791c52cf7e0a8ab
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publicationDate 2017-03-09^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2017065719-A1
titleOfInvention Compounds and methods for the targeted degradation of bromodomain-containing proteins
abstract The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.
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