| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4ec5a4405df872f61cc17180fc5b3d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a75c3c08a3c43da8a64ae0ec6c58a3b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01008 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18 |
| filingDate |
2017-05-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6006d625d03ed5e99b70b7cb57a7310
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a800357ec7bc98d55439a73d241c0f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc90cc2cc1a9f47074c9dde124f118e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba0394bf6ffa69f91288d21f20301870
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6907a5607b2eb0a4ad72a356fc61226a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36351dc9140bf219f68acfae7b84e146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8317694ada6bb732da3b8a5e9553a906 |
| publicationDate |
2017-11-02^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017313999-A1 |
| titleOfInvention |
Plant-Based Recombinant Butyrylcholinesterase Production Methods |
| abstract |
A new, reliable, easily scalable and reproducible method for the production of recombinant butyrylcholinesterase (rBuChE) is provided. Through the utilization of a plant transfection procedure, various plant strains have been shown to generate effective and scalable amounts of rBuChE under acceptable manufacturing processes to permit reliable levels of such enzymes for desired nerve agent protection requirements (including tetrameric products). As well, such methods in engineered plant lines have shown suitable production of these enzymes in tetramer form with glycan formation and sialylation (for terminal groups) to allow for optimal potency against organophosphorus agent exposure as well as proper immunogenic response within the plant sources. The overall production method, including the transfection and production within mammalian cells, as well as the process steps involved for such a reliable sourcing platform from plants is thus encompassed within the invention. |
| priorityDate |
2013-10-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |