http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018179497-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17441447e5e82872084d7db0ff728f8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9eb0bce2d6741beaa1923456ec3f8c9e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11B5-0085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11C3-06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0642 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-103 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0787 |
| filingDate | 2017-12-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e17892b5c8cb59852958c977e101599 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8394c81f6aa93b40c04f764b17d4f69a |
| publicationDate | 2018-06-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2018179497-A1 |
| titleOfInvention | Artificial immune cell emulating selected properties of granulocytes utilizing Fenton-type reactions |
| abstract | An artificial immune cell emulating certain properties of the granulocytes is disclosed as a construct or aggregate of several constituent particles that possess the properties of catalysis therefore producing free radicals and reactive species of oxygen, nitrogen, halogens and the like in the classical Fenton and Fenton-like reactions with produced free radicals serving as signaling molecules and, in higher concentrations, as toxic factors for microorganisms, cancerous cells, abnormal tissue and other biological targets, emulating the production of free radicals by natural immune cells. Motility of the artificial immune cell is facilitated by magnetotactic and other means, as some or all of the constituent particles possess magnetic, especially superparamagnetic properties which may be provided by the same catalytic components since said particles such as those containing compounds such as magnetite, maghemite, and substituted ferrites are capable of catalyzing Fenton-type reactions. Constituent particles of the artificial immune cell may be coated with agents facilitating specific targeting and binding such as antibodies to target antigenes, they may also interact with the intrinsically present natural immune cells by presenting antigens or antibody fragments. Other constituent particles of the artificial immune cell may be coated with lipid bilayers with sequestered biologically active molecules that are released as the lipid bilayer is destroyed by free radicals or they may contain cavities or internal spaces filled with biologically active molecules and capped or sealed with easily oxidizable materials facilitating the release of such molecules in the presence of aggressive oxidants such, thus emulating the property of granulocytes known as degranulation. A variety of the constituent particle may be a capped hollow cylinder with the internal walls presenting with excess of negative electric charges and filled with compacted nucleic acid-protein mixtures whereas upon destruction of the caps the repulsive electric force pushes out the nucleic acid-protein mixture emulating the property of neutrophils known as formation of neutrophil extracellular traps. Modification, modulation and termination of the activity of the artificial immune cell is accomplished by removal by magnetotactic locomotion, disruption with energetic waves, extinguishing of Fenton and Fenton-type reactions by introduction of reaction termination conditions such as excess of antioxidants. Additional refinements are disclosed with specific chemical and physical alterations of the constituent particles or the complete artificial immune cell. |
| priorityDate | 2016-12-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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