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filingDate 2018-05-21^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-12-13^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2018355064-A1
titleOfInvention Production of t cell retargeting hetero-dimeric immunoglobulins
abstract The present invention describes novel hetero-dimeric immunoglobulins or fragments thereof which bind to CD3 and a disease associated antigen. These hetero-dimeric immunoglobulins have been engineered to promote hetero-dimer formation during expression and can be purified to a high degree using a Protein A differential purification technique.
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