| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7028 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate |
2017-03-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c4fba8396358e9516d1c0cd7e503b60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_755c69fe904d3fd0e2a370ed0c92e612 |
| publicationDate |
2019-02-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019055543-A1 |
| titleOfInvention |
Molecular Cell Diary System |
| abstract |
The subject invention pertains to a Molecular Cell Diary System (MCDS), which allows identification of the history of somatic alterations in the cell. MCDS comprises one or more combinations of a DNA cutter and a DNA writer expressed under the control of a promoter controlled a cellular event of interest. The DNA cutter and the DNA writer are in a combination are co-expressed when an even of interest occurs. The DNA cutter creates double strand breaks (DSB) in a target DNA in a sequence specific manner and the DNA writer incorporates DNA sequences in the DSB. The endogenous DNA repair machinery synthesizes repairs the DSB. As such, the combination of the DNA cutter and the DNA writer modifies the target DNA and leaves “marks” of the occurrence of the cellular event of interest. These marks are sequenced and the cellular event history of the cell is deciphered. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111979238-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11306324-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11732274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542496-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11326161-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702651-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11661590-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11319532-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11643652-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11560566-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542509-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11214780-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11447770-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11268082-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11572556-B2 |
| priorityDate |
2016-03-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |