| abstract |
New norcamphane derivatives bearing at the 3-position a 2hydroxyethylamino, 2-haloethylamino, ethyleneimino, or cyclopropylmethylamino group, having useful hypotensive activity, and prepared, respectively, by alkylation of 3-amino-2,2,3trimethylnorcamphane with ethylene oxide; halogenation of the resulting 3-(2-hydroxyethylamino)-2,2,3-trimethylnorcamphane; cyclization, in the presence of alkali, of the resulting 3-(2haloethylamino)-2,2,3-trimethylnorcamphane; or acylation of 3amino-2,2,3-trimethylnorcamphane with a cyclopropylcarbonyl halide and alkali metal aluminum hydride reduction of the resulting 3-cyclopropylcarbonylamino-2,2,3-trimethylnorcamphane. |