| abstract |
A NOVEL CLASS OF ANTIINFLAMMATORY AGENTS OF THE FORMULAE 1-R1,2-R2,4-AR,5-AR''-IMIDAZOLE 1-R1,2-AR'',4-AR,5-R2-IMIDAZOLE 1-R1,2-AR'',4-R2,5-AR-IMIDAZOLE WHERE AR AND AR'' ARE EACH FURYL, THIENYL, PYRIDYL, PHENYL OR SUBSTITUTED PHENYL; R1 IS HYDROGEN, ALKYL OR ALKENYL; R2 IS TRIFLUOROMETHYL, ALKYL, FURYL, THIENYL, PYRIDYL, PHENYL OR SUBSTITUTED PHENYL AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS, AS WELL AS METHODS FOR THEIR SYNTHESIS, ARE DESCRIBED. |