| abstract |
Substituted nitroimidazoles having a 1-alkyl or hydroxyalkyl substituent; a 5-nitro substituent; and a 2-substituent, the latter being a Delta 2-4,5-disubstituted-isoxazoline. The 4,5substitution on the isoxazolinemoiety is a saturated alkyl ring structure. These compounds have anti-bacterial and anti-protozoal activity against human and animal trypanosomiasis and trichomoniasis. |