| abstract |
Piperazine derivatives having the formula WHEREIN EACH OF X1 and X2 is H, Cl, CH3, CH3O or CF3; Y is thienyl, furyl, pyridyl, thiazolyl, phenyl or substituted phenyl, in which the phenyl substituents are 1 or 2 groups selected from the group consisting of Cl, CH3, CH3O and CF3; Z is -S-, -SO2-, O-, -NR- or -SO2-NR-, in which R is an alkyl group having from 1 to 4 carbon atoms; n is 2 or 3; and m is 0, 1 or 2; and the pharmaceutically acceptable acid addition salts thereof are disclosed. The piperazine derivatives and their pharmaceutically acceptable addition salts are useful as anti-allergics, psychotropics and analgesics. |