| abstract |
DIPEPTIDE ANTIBIOTIC FUMARYLCARBOXYAMIDO-L-2,3- DIAMINOPROPIONYL-L-ALANINE IS PRODUCED BY CULTURING THE ORGANISM STREPTOMYCES COLLINUS NRRL 5332 UNDER SUBMERGED AEROBIC FERMENTATION CONDITIONS AND IS ISOLATED BY CHROMATOGRAPHY OF THE FILTERED FERMENTATION BROTH OVER ACTIVATED CARBON, FOLLOWED BY CHROMATOGRAPHY OF THE ACTIVE FRACTIONS OBTAINED THEREFROM OVER ACID-WASHED ALUMINA. THE ANTIBIOTIC DISPLAYS SIGNIFICANT ACTIVITY AGAINST SALMONELLA GALLINARUM AND TRICHOMONAS VAGINALIS. |