| abstract |
Arylpiperazines of the formula R-A-Z wherein R is OR R2-Q-, in which R1 is H, alkyl, Ar or COR3; R2 is H or alkyl; R3 is alkyl, aralkyl or substituted or unsubstituted aryl, and Q is -CX1 CH-CO-, -C*C-CO-, -CH CX1-CO-, -CHX1-CHX1-CO-, -COCH CX1-, -CO-C*C-, -CO-CX1 CH- or -CO-CHX1-CHX1; X1 is a functional group; A is CnH2n in which n is 1-4; Z is AND Ar is unsubstituted or substituted phenyl; are produced by reacting a carbonyl compound of the formula R2-Q-Y wherein Y is A-X1 or -CnH2n-1, with a compound of the formula H-Z to produce novel intermediate products of the formula R2-Q-A-Z which can then be reacted with a hydrazine derivative of the formula R1-NHNH2 to produce a pyrazolylalkyl piperazine as defined above. |