| abstract |
Isatoic anhydrides of the formula: <IMAGE> wherein R is alkyl, phenyl or phenalkyl and R1 and R2 are hydrogen, halo, alkyl, alkoxy or together methylenedioxy are intermediates reactable with an acyclic 5-methyl-thiopseudourea and acetonitrile to pharmaceutical agents, for example, analgetic and hypotensive agents, of the formula: <IMAGE> wherein R, R1 and R2 are as defined and Ro is hydrogen, alkyl, omega -alkenyl or phenyl. |