| abstract |
Antimicrobial compounds are disclosed having the formula: n n Z--B--Y--B--Z .nHA n n wherein B is carbamylguanidino, or thiocarbamylguanidino, Y is a bivalent organic radical selected from the group consisting of C 2 -C 12 alkylene, C 5 -C 12 cycloalkylene, C 5 -C 12 cycloalkylenebis(loweralkyl), C 6 -C 12 arylene and loweralkylarylene, C 7 -C 12 aryleneloweralkyl, and C 8 -C 12 arylenebis(loweralkyl) and Z is selected from the group consistng of C 1 -C 2 alkyl; C 4 -C 12 dialkylaminoalkyl; C 3 -C 12 alkenyl; C 3 -C 12 alkynyl; C 3 -C 12 cycloalkyl, C 4 -C 12 cycloalkylalkyl; C 1 -C 10 alkoxy C 10 -C 2 alkyl having a total carbon content of C 3 -C 14 ; C 1 -C 10 alkythio C 10 -C 2 alkyl having a total carbon content of C 3 -C 14 ; phenoxy C 2 -C 6 alkyl; phenylthio C 2 -C 6 alkyl; C 6 -C 14 aryl; C 7 -C 14 aralkyl and arylcycloalkyl; and C 6 -C 14 aryl and aralkyl substituted with one or more radicals selected from the group consisting of loweralkyl, trifluoromethyl, loweralkoxy, trifluoromethoxy, phenoxy, loweralkylthio, halo, nitro, cyano, C 2 -C 6 acyl, benzoyl, alkoxycarbonyl, diloweralkylamino, loweralkylsulfonyl, fluorosulfonyl and alkylsulfinyl; n=0, 1/3, 1/2, 2/3, 1, 2 and HA is an inorganic or organic acid. |