http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4180437-A

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filingDate 1977-03-01^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1979-12-25^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3eb583abb3dca737901da03a586add5
publicationDate 1979-12-25^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4180437-A
titleOfInvention Purification of antiserum for thrombosis test
abstract Antiserum which has been generated against an enzyme-inhibitor-complex is purified by immunoprecipitating a freshly generated antiserum with fresh human bloodplasma to form a precipitate and a fluid, and subjecting the fluid to chromatographic separation over an insolubilized enzyme-inhibitor complex against which the antiserum has been generated. A reagent for immunochemical assay is prepared by contacting the purified antiserum with red bloodcells or synthetic resin particles to obtain on the surface of the red bloodcells or synthetic resin particles antibodies from the antiserum. In a diagnosis test, blood plasma is contacted with the purified antiserum and with red bloodcells or synthetic resin particles which bear the enzyme-inhibitor complex used to prepare the antiserum, and whether or not agglutination occurs is ascertained. In an alternative diagnosis test, blood plasma is contacted with red bloodcells or synthetic resin particles having on their surface antibodies from the antiserum, and whether or not agglutination occurs is ascertained.
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priorityDate 1976-03-08^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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