| abstract |
The invention relates to novel omega -aminocarboxylic acid amides having the formula (I) <IMAGE> (I) wherein A is -SO2OH or -OPO(OH)2, R1 is hydrogen, an acyl group, such as benzoyl, arylsulfonyl, alkoxycarbonyl, cycloalkoxycarbonyl or aralkoxycarbonyl group or an aralkoxycarbonyl group having a halogen, alkoxy, nitro, phenylazo or alkoxyphenylazo substituent, alkyl-substituted aryloxycarbonyl or carbonyl, R2 is hydrogen or a carbonyl group, with the proviso that when R1 and R2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is -SO2OH and R1 is an acyl group such as benzoyl, aryl sulfonyl, alkoxy-carbonyl, cycloalkoxycarbonyl or aryloxycarbonyl group or an aralkoxy carbonyl group having a halogen, alkoxy, nitro, phenylozo or alkoxyphenylazo substituent or an alkyl-substituted aryloxycarbonyl group or carbonyl group, R2 is hydrogen or a carbonyl group, with the proviso that when R1 and R2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is -O-P-O(OH)2 and n is equal to 2 or 3, and salts of the above compounds, furthermore to a process for the preparation thereof. The novel compounds according to the invention possess valuable pharmacological effects in reducing blood sugar levels or can be applied as intermediate in the synthesis of biologically active compounds. |