| abstract |
Prostaglandin analogs are disclosed that have the alpha -chain terminating with the group -CH(OR')OR'' wherein R' and R'' are the same or different and are hydrogen, C1 to C4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C1 to C4 alkyl, C1 to C4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators. |